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Xiao, T., Sun, M., & Zhao, C. (2023). Trpv1: A promising therapeutic target for skin aging and inflammatory skin diseases. Frontiers in Pharmacology, 14. 
Added by: Dr. Enrique Feoli (08/12/2023, 19:19)   Last edited by: Dr. Enrique Feoli (20/02/2024, 18:57)
Resource type: Journal Article
DOI: 10.3389/fphar.2023.1037925
ID no. (ISBN etc.): 1663-9812
BibTeX citation key: Xiao2023
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 Categories: BioAcyl Corp, BioAcyl Corp, BioAcyl Corp
Subcategories: Dermatologia, Dermatosis, TPRV1
Creators: Sun, Xiao, Zhao
Collection: Frontiers in Pharmacology		 Views: 2/438
Abstract
TRPV1 is a non-selective channel receptor widely expressed in skin tissues, including keratinocytes, peripheral sensory nerve fibers and immune cells. It is activated by a variety of exogenous or endogenous inflammatory mediators, triggering neuropeptide release and neurogenic inflammatory response. Previous studies have shown that TRPV1 is closely related to the occurrence and/or development of skin aging and various chronic inflammatory skin diseases, such as psoriasis, atopic dermatitis, rosacea, herpes zoster, allergic contact dermatitis and prurigo nodularis. This review summarizes the structure of the TRPV1 channel and discusses the expression of TRPV1 in the skin as well as its role of TRPV1 in skin aging and inflammatory skin diseases.
  
Notes

www.frontiersin.org

The expression of TRPV1 in the skin. TRPV1 channel is not only expressed in sensory nerve fibers innervating the skin but also in different non-neuronal cells, which contribute to maintaining normal skin physiology or play important roles in the pathogenesis of skin diseases.


Added by: Dr. Enrique Feoli  Last edited by: Dr. Enrique Feoli
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