BioAcyl Corp
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Ravasz, E., Somera, A. L., Mongru, D. A., & others. (2002). Hierarchical Organization of Modularity in Metabolic Networks. Science, 297(5586), 1551–1555. Added by: Dr. Enrique Feoli (08/02/2021, 02:16) Last edited by: Dr. Enrique Feoli (08/02/2021, 02:18) |
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| Resource type: Journal Article DOI: 10.1126/science.1073374 ID no. (ISBN etc.): 0036-8075 BibTeX citation key: Ravasz2002 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Network Medicine Creators: Mongru, others, Ravasz, Somera Collection: Science |
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| Abstract |
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Spatially or chemically isolated functional modules composed of several cellular components and carrying discrete functions are considered fundamental building blocks of cellular organization, but their presence in highly integrated biochemical networks lacks quantitative support. Here, we show that the metabolic networks of 43 distinct organisms are organized into many small, highly connected topologic modules that combine in a hierarchical manner into larger, less cohesive units, with their number and degree of clustering following a power law. Within Escherichia coli, the uncovered hierarchical modularity closely overlaps with known metabolic functions. The identified network architecture may be generic to system-level cellular organization.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |