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Romao, S., Gasser, N., & Becker, A. C. (2013). Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing. Journal of Cell Biology, 203(5), 757–766. Added by: Dr. Enrique Feoli (02/05/2024, 11:38) Last edited by: Dr. Enrique Feoli (29/12/2025, 18:54) |
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| Resource type: Journal Article DOI: 10.1083/jcb.201308173 ID no. (ISBN etc.): 0021-9525 BibTeX citation key: Romao2013 View all bibliographic details  |
Categories: ARIA, BioAcyl Corp Subcategories: Autophagy and mitophagy Creators: Becker, Gasser, Romao Collection: Journal of Cell Biology |
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| Abstract |
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{Antigen preservation for presentation is a hallmark of potent antigen-presenting cells. In this paper, we report that in human macrophages and dendritic cells, a subset of phagosomes gets coated with Atg8/LC3, a component of the molecular machinery of macroautophagy, and maintains phagocytosed antigens for prolonged presentation on major histocompatibility complex class II molecules. These Atg8/LC3-positive phagosomes are formed around the antigen with TLR2 agonists and require reactive oxygen species production by NOX2 for their generation. A deficiency in the NOX2-dependent formation of these antigen storage phagosomes could contribute to compromise antifungal immune control in chronic granulomatous disease patients.}
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