BioAcyl Corp
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Zhuang, Y., Jiang, S., & Deng, X. (2024). Energy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle. Science Advances, 10(15), eadl0372. Added by: Dr. Enrique Feoli (14/07/2025, 17:35) Last edited by: Dr. Enrique Feoli (14/07/2025, 17:42) |
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| Resource type: Journal Article DOI: 10.1126/sciadv.adl0372 BibTeX citation key: Zhuang2024 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Senescent cells Creators: Deng, Jiang, Zhuang Collection: Science Advances |
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| Abstract |
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Aging skin, vulnerable to age-related defects, is poor in wound repair. Metabolic regulation in accumulated senescent cells (SnCs) with aging is essential for tissue homeostasis, and adequate ATP is important in cell activation for aged tissue repair. Strategies for ATP metabolism intervention hold prospects for therapeutic advances. Here, we found energy metabolic changes in aging skin from patients and mice. Our data show that metformin engineered EV (Met-EV) can enhance aged mouse skin repair, as well as ameliorate cellular senescence and restore cell dysfunctions. Notably, ATP metabolism was remodeled as reduced glycolysis and enhanced OXPHOS after Met-EV treatment. We show Met-EV rescue senescence-induced mitochondria dysfunctions and mitophagy suppressions, indicating the role of Met-EV in remodeling mitochondrial functions via mitophagy for adequate ATP production in aged tissue repair. Our results reveal the mechanism for SnCs rejuvenation by EV and suggest the disturbed energy metabolism, essential in age-related defects, to be a potential therapeutic target for facilitating aged tissue repair. The disturbed ATP metabolism could be a potential target for rescuing senescent cells and improving aged tissue repair.
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Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
