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Chaudhry, A., & Rudensky, A. Y. (2013). Control of inflammation by integration of environmental cues by regulatory T cells. The Journal of Clinical Investigation, 123(3), 939–944. Added by: Dr. Enrique Feoli (16/07/2025, 22:18) Last edited by: Dr. Enrique Feoli (16/07/2025, 22:19) |
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| Resource type: Journal Article DOI: 10.1172/JCI57175 BibTeX citation key: Chaudhry2013 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Tregs Creators: Chaudhry, Rudensky Collection: The Journal of Clinical Investigation |
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| Abstract |
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Tregs have been implicated in control of homeostasis in the immune system and beyond. These cells restrain inflammatory responses to self antigens, commensal microorganisms, allergens, and pathogens and adapt their homeostatic and functional capabilities to a particular environment. In this review, we discuss a general model of integration of environmental cues by Tregs in which specialized Treg homeostatic, migratory, and suppression programs are established in dynamically changing inflammatory environments by maintaining an optimal threshold of activation of transcription factors involved in regulation of the corresponding type of effector immune responses.
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| Notes |
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Publisher: The American Society for Clinical Investigation
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