Glycans on Secretory Component Participate in Innate Protection against Mucosal Pathogens *

Perrier, Clémentine; Sprenger, Norbert; Corthésy, Blaise

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BioAcyl Corp

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Perrier, C., Sprenger, N., & Corthésy, B. (2006). Glycans on Secretory Component Participate in Innate Protection against Mucosal Pathogens *. Journal of Biological Chemistry, 281(20).
Added by: Dr. Enrique Feoli (03/01/2026, 19:00) Last edited by: Dr. Enrique Feoli (03/01/2026, 19:10)

Resource type: Journal Article
ID no. (ISBN etc.): 0021-9258
BibTeX citation key: Perrier2006
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Categories: BioAcyl Corp
Subcategories: Salivary IgA
Keywords: sIgA
Creators: Corthésy, Perrier, Sprenger
Publisher: JMC
Collection: Journal of Biological Chemistry

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Abstract

In mucosal secretions, secretory component (SC) is found either free or bound to polymeric IgA within the secretory IgA complex. SC displays numerous and various glycans, which are potential ligands for bacterial compounds. We first established that human SC (hSC) purified from colostrum (hSCcol) or produced in Chinese hamster ovary cells (hSCrec) exhibits the same lectin reactivity. Both forms bind to Clostridium difficile toxin A and functionally protect polarized Caco-2 cell monolayers from the cytopathic effect of the toxin.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli