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Vanhatalo, A., L'Heureux, J. E., & Kelly, J. (2021). Network analysis of nitrate-sensitive oral microbiome reveals interactions with cognitive function and cardiovascular health across dietary interventions. Redox Biology, 41, 101933. Added by: Dr. Enrique Feoli (23/02/2026, 20:21) Last edited by: Dr. Enrique Feoli (23/02/2026, 20:22) |
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| Resource type: Journal Article DOI: 10.1016/j.redox.2021.101933 ID no. (ISBN etc.): 2213-2317 BibTeX citation key: Vanhatalo2021 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Entero-salivary cycle Keywords: Aging, nitric oxide, Oral microbiome Creators: Kelly, L'Heureux, Vanhatalo Collection: Redox Biology |
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| Abstract |
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Many oral bacteria reduce inorganic nitrate, a natural part of a vegetable-rich diet, into nitrite that acts as a precursor to nitric oxide, a regulator of vascular tone and neurotransmission. Aging is hallmarked by reduced nitric oxide production with associated detriments to cardiovascular and cognitive function. This study applied a systems-level bacterial co-occurrence network analysis across 10-day dietary nitrate and placebo interventions to test the stability of relationships between physiological and cognitive traits and clusters of co-occurring oral bacteria in older people. Relative abundances of Proteobacteria increased, while Bacteroidetes, Firmicutes and Fusobacteria decreased after nitrate supplementation. Two distinct microbiome modules of co-occurring bacteria, that were sensitive to nitrate supplementation, showed stable relationships with cardiovascular (Rothia-Streptococcus) and cognitive (Neisseria-Haemophilus) indices of health across both dietary conditions. A microbiome module (Prevotella-Veillonella) that has been associated with pro-inflammatory metabolism was diminished after nitrate supplementation, including a decrease in relative abundance of pathogenic Clostridium difficile. These nitrate-sensitive oral microbiome modules are proposed as potential pre- and probiotic targets to ameliorate age-induced impairments in cardiovascular and cognitive health.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |