BioAcyl Corp
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Liu, D., Yang, J., & Cristea, I. M. (2024). Liquid–liquid phase separation in innate immunity. Trends in Immunology, 45(6), 454–469. Added by: Dr. Enrique Feoli (21/04/2026, 20:21) Last edited by: Dr. Enrique Feoli (21/04/2026, 20:22) |
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| Resource type: Journal Article DOI: 10.1016/j.it.2024.04.009 ID no. (ISBN etc.): 1471-4906 BibTeX citation key: Liu2024 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Liquid-liquid phase separations Creators: Cristea, Liu, Yang Collection: Trends in Immunology |
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| Abstract |
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Liquid?liquid phase separation (LLPS) has emerged as a key mechanism regulating innate immunity, and dynamically organizing immune factors to achieve rapid responses.LLPS tightly regulates DNA and RNA sensing pathways, inflammasome activation, as well as stress granule and PML nuclear body formation.Viruses dysregulate or exploit LLPS mechanisms to evade host defenses and promote infection.Post-translational modifications, such as phosphorylation and acetylation, provide dynamic regulatory toggles for LLPS, dictating the formation and disassembly of biomolecular condensates in immune cell signaling for rapid and plastic responses.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
| Notes |
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doi: 10.1016/j.it.2024.04.009
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |