BioAcyl Corp
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Seow, J., Graham, C., Merrick, B., Acors, S., Steel, K. J. A., & Hemmings, O., et al. (2020). Longitudinal evaluation and decline of antibody responses in SARS-CoV-2 infection. medRxiv, 2020.07.09.20148429. Added by: Dr. Enrique Feoli (14/07/2020, 19:13) Last edited by: Dr. Enrique Feoli (14/07/2020, 19:14) |
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| Resource type: Journal Article DOI: 10.1101/2020.07.09.20148429 ID no. (ISBN etc.): 2014-8429 BibTeX citation key: Seow2020 View all bibliographic details  |
Categories: Zotero Subcategories: COVID-19 Creators: Acors, Arbane, Batra, Betancor, Bisnauthsing, Doores, Douthwaite, Edgeworth, Galao, Graham, Green, Hara, Hemmings, Honey, Izquierdo-Barras, Kerridge, Kouphou, MacMahon, Malim, Martinez, Martinez-Nunez, Merrick, Moore, Nebbia, Neil, O'Bryne, OConnell, Patel, Pickering, Seow, Signell, Snell, Steel, Stokes, Temperton, Wilson, Winstone Collection: medRxiv |
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| Abstract |
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{<}p{>}Antibody (Ab) responses to SARS-CoV-2 can be detected in most infected individuals 10-15 days following the onset of COVID-19 symptoms. However, due to the recent emergence of this virus in the human population it is not yet known how long these Ab responses will be maintained or whether they will provide protection from re-infection. Using sequential serum samples collected up to 94 days post onset of symptoms (POS) from 65 RT-qPCR confirmed SARS-CoV-2-infected individuals, we show seroconversion in >95% of cases and neutralizing antibody (nAb) responses when sampled beyond 8 days POS. We demonstrate that the magnitude of the nAb response is dependent upon the disease severity, but this does not affect the kinetics of the nAb response. Declining nAb titres were observed during the follow up period. Whilst some individuals with high peak ID$_{textrm{50}}$ (>10,000) maintained titres >1,000 at >60 days POS, some with lower peak ID$_{textrm{50}}$ had titres approaching baseline within the follow up period. A similar decline in nAb titres was also observed in a cohort of seropositive healthcare workers from Guy′s and St Thomas′ Hospitals. We suggest that this transient nAb response is a feature shared by both a SARS-CoV-2 infection that causes low disease severity and the circulating seasonal coronaviruses that are associated with common colds. This study has important implications when considering widespread serological testing, Ab protection against re-infection with SARS-CoV-2 and the durability of vaccine protection.{<}/p{>}
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| Notes |
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Publisher: Cold Spring Harbor Laboratory Press
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