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Long, Q.-X., Tang, X.-J., Shi, Q.-L., & others. (2020). Clinical and immunological assessment of asymptomatic sars-cov-2 infections - nature medicine. Nat. Med. 26(8), 1200–1204. Added by: Dr. Enrique Feoli (11/01/2022, 15:24) Last edited by: Dr. Enrique Feoli (11/01/2022, 15:25) |
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| Resource type: Journal Article DOI: 10.1038/s41591-020-0965-6 ID no. (ISBN etc.): 1546-170X BibTeX citation key: Long2020 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Asymptomatic COVID-19 Creators: Long, others, Shi, Tang Collection: Nat. Med. |
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| Abstract |
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The clinical features and immune responses of asymptomatic individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have not been well described. We studied 37 asymptomatic individuals in the Wanzhou District who were diagnosed with RT{textendash}PCR-confirmed SARS-CoV-2 infections but without any relevant clinical symptoms in the preceding 14 d and during hospitalization. Asymptomatic individuals were admitted to the government-designated Wanzhou People{'}s Hospital for centralized isolation in accordance with policy1. The median duration of viral shedding in the asymptomatic group was 19 d (interquartile range (IQR), 15{textendash}26 d). The asymptomatic group had a significantly longer duration of viral shedding than the symptomatic group (log-rank P{hspace{0.167em}}={hspace{0.167em}}0.028). The virus-specific IgG levels in the asymptomatic group (median S/CO, 3.4; IQR, 1.6{textendash}10.7) were significantly lower (P{hspace{0.167em}}={hspace{0.167em}}0.005) relative to the symptomatic group (median S/CO, 20.5; IQR, 5.8{textendash}38.2) in the acute phase. Of asymptomatic individuals, 93.3{%} (28/30) and 81.1{%} (30/37) had reduction in IgG and neutralizing antibody levels, respectively, during the early convalescent phase, as compared to 96.8{%} (30/31) and 62.2{%} (23/37) of symptomatic patients. Forty percent of asymptomatic individuals became seronegative and 12.9{%} of the symptomatic group became negative for IgG in the early convalescent phase. In addition, asymptomatic individuals exhibited lower levels of 18 pro- and anti-inflammatory cytokines. These data suggest that asymptomatic individuals had a weaker immune response to SARS-CoV-2 infection. The reduction in IgG and neutralizing antibody levels in the early convalescent phase might have implications for immunity strategy and serological surveys.
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