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Liu, J., Wang, J., Xu, J., Xia, H., Wang, Y., & Zhang, C., et al. (2021). Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines. Cell Discovery, 7(1), 1–15. Added by: Dr. Enrique Feoli (31/01/2022, 08:39) Last edited by: Dr. Enrique Feoli (31/01/2022, 09:42) |
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| Resource type: Journal Article DOI: 10.1038/s41421-021-00329-3 ID no. (ISBN etc.): 2056-5968 BibTeX citation key: Liu2021a View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: COVID-19 Creators: Chen, Deng, Gao, Lin, Liu, Liu, Liu, Shao, Shen, Shi, Shi, Sun, Wang, Wang, Wang, Wu, Xia, Xing, Xu, Yang, Zhang, Zhang, Zheng, Zhou, Zhu, Zhu Collection: Cell Discovery |
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| Abstract |
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Large-scale COVID-19 vaccinations are currently underway in many countries in response to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies, consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an inactivated SARS-CoV-2 vaccine. Similar changes had also been reported in COVID-19 patients, suggesting that vaccination mimicked an infection. Single-cell mRNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) before and 28 days after the first inoculation also revealed consistent alterations in gene expression of many different immune cell types. Reduction of CD8+ T cells and increase in classic monocyte contents were exemplary. Moreover, scRNA-seq revealed increased NF-κB signaling and reduced type I interferon responses, which were confirmed by biological assays and also had been reported to occur after SARS-CoV-2 infection with aggravating symptoms. Altogether, our study recommends additional caution when vaccinating people with pre-existing clinical conditions, including diabetes, electrolyte imbalances, renal dysfunction, and coagulation disorders.
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Number: 1 Publisher: Nature Publishing Group
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