BioAcyl Corp
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Medzhitov, R. (2021). The spectrum of inflammatory responses. Science, 374(6571), 1070–1075. Added by: Dr. Enrique Feoli (16/04/2023, 17:18) Last edited by: Dr. Enrique Feoli (16/04/2023, 17:28) |
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| Resource type: Journal Article DOI: 10.1126/science.abi5200 BibTeX citation key: Medzhitov2021 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: inflammation Creators: Medzhitov Collection: Science |
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| Abstract |
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Inflammation is an integral part of animal biology. It provides critical protection from adverse environmental factors by enforcing the defense of homeostasis and the functional and structural integrity of tissues and organs. Recent advances have uncovered a broad range of biological processes that involve inflammatory control, calling for a renewed framework of inflammation beyond its classical roles in defense from infection and injury. In this Review, new perspectives on inflammation biology are discussed and new research directions are suggested to address the fundamental gaps in our current understanding.
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| Notes |
Inflammatory pathways consist of an inflammatory stimulus, sensors, and inflammatory signals that act on two types of targets. One type is the inflammatory effectors, such as neutrophils, monocytes, and eosinophils. Effectors eliminate the cause of inflammation. This is a negative feedback (resistance) part of the circuit. Another type of target are tissues and organs that change their functional state to adapt to the perturbation and to support the effector response. This is a feedforward (adaptation/tolerance) part of the circuit. Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |