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Varian, B. J., Weber, K. T., & Erdman, S. E. (2023). Oxytocin and the microbiome. Comprehensive Psychoneuroendocrinology, 16, 100205. Added by: Dr. Enrique Feoli (04/11/2023, 20:19) Last edited by: Dr. Enrique Feoli (04/11/2023, 20:23) |
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| Resource type: Journal Article DOI: https://doi.org/10.1016/j.cpnec.2023.100205 ID no. (ISBN etc.): 2666-4976 BibTeX citation key: Varian2023 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Microbiota on immunity Creators: Erdman, Varian, Weber Collection: Comprehensive Psychoneuroendocrinology |
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| Abstract |
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The mammalian host microbiome affects many targets throughout the body, at least in part through an integrated gut-brain-immune axis and neuropeptide hormone oxytocin. It was discovered in animal models that microbial symbionts, such as Lactobacillus reuteri, leverage perinatal niches to promote multigenerational good health and reproductive fitness. While roles for oxytocin were once limited to women, such as giving birth and nurturing offspring, oxytocin is now also proposed to have important roles linking microbial symbionts with overall host fitness and survival throughout the evolutionary journey.
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| Notes |
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The gut microbiome modulates host immune responses via the gut-brain-immune axis through a variety of mechanisms including microbial community dynamics and circulating microbial products and immune factors. Among these mechanisms, the vagus nerve allows gut microbes to communicate with the brain and modulate the immune system and maintain homeostasis in the host's body. As demonstrated in Poutahidis et al., 2013, vagotomies, which sever this line of communication, block gut-mediated immune modulation affecting the circulation, distribution, activation and potency of various immune cells [10]. Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
