BioAcyl Corp
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Mestecky, J., & Russell, M. W. (2009). Specific antibody activity, glycan heterogeneity and polyreactivity contribute to the protective activity of S-IgA at mucosal surfaces. Immunology letters, 124(2), 57–62. Added by: Dr. Enrique Feoli (06/01/2026, 12:09) Last edited by: Dr. Enrique Feoli (06/01/2026, 12:10) |
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| Resource type: Journal Article DOI: 10.1016/j.imlet.2009.03.013 ID no. (ISBN etc.): 0165-2478 BibTeX citation key: Mestecky2009 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Salivary IgA Keywords: Bacterial adherence, Glycans, Mucosal immunity, Secretory IgA Creators: Mestecky, Russell Collection: Immunology letters |
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| Abstract |
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An explanation of the principles and mechanisms involved in peaceful co-existence between animals and the huge, diverse, and ever-changing microbiota that resides on their mucosal surfaces represents a challenging puzzle that is fundamental in everyday survival. In addition to mechanical barriers and a variety of innate defense factors, mucosal immunoglobulins (Igs) provide protection by two complementary mechanisms: specific antibody activity and innate, Ig glycan-mediated binding, both of which serve to contain the mucosal microbiota in its physiological niche. Thus, the interaction of bacterial ligands with IgA glycans constitutes a discrete mechanism that is independent of antibody specificity and operates primarily in the intestinal tract. This mucosal site is by far the most heavily colonized with an enormously diverse bacterial population, as well as the most abundant production site for antibodies, predominantly of the IgA isotype, in the entire immune system. In embodying both adaptive and innate immune mechanisms within a single molecule, S-IgA maintains comprehensive protection of mucosal surfaces with economy of structure and function.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |