BioAcyl Corp
BioAcyl Corp |
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Sharpe, P. T. (2016). Dental mesenchymal stem cells. Development, 143(13), 2273–2280. Added by: Dr. Enrique Feoli (25/07/2020, 17:15) Last edited by: Dr. Enrique Feoli (25/07/2020, 17:16) |
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| Resource type: Journal Article DOI: 10.1242/dev.134189 ID no. (ISBN etc.): 0950-1991 BibTeX citation key: Sharpe2016 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Dentin-Pulp interface Creators: Sharpe Collection: Development Resources citing this (Bibliography: WIKINDX Master Bibliography) |
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| Abstract |
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Mammalian teeth harbour mesenchymal stem cells (MSCs), which contribute to tooth growth and repair. These dental MSCs possess many in vitro features of bone marrow-derived MSCs, including clonogenicity, expression of certain markers, and following stimulation, differentiation into cells that have the characteristics of osteoblasts, chondrocytes and adipocytes. Teeth and their support tissues provide not only an easily accessible source of MSCs but also a tractable model system to study their function and properties in vivo. In addition, the accessibility of teeth together with their clinical relevance provides a valuable opportunity to test stem cell-based treatments for dental disorders. This Review outlines some recent discoveries in dental MSC function and behaviour and discusses how these and other advances are paving the way for the development of new biologically based dental therapies.
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