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Fukuyama, Y., Tokuhara, D., Sekine, S., & others. (2013). Potential roles of ccr5+ ccr6+ dendritic cells induced by nasal ovalbumin plus flt3 ligand expressing adenovirus for mucosal iga responses. PloS one, 8(4), e60453. Added by: Dr. Enrique Feoli (28/01/2022, 14:32) Last edited by: Dr. Enrique Feoli (28/01/2022, 14:35) |
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| Resource type: Journal Article DOI: 10.1371/journal.pone.0060453 ID no. (ISBN etc.): 1932-6203 BibTeX citation key: Fukuyama2013 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Inmunidad de mucosas Creators: Fukuyama, others, Sekine, Tokuhara Collection: PloS one |
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| Abstract |
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We assessed the role of CCR5+/CCR6+/CD11b+/CD11c+ dendritic cells (DCs) for induction of ovalbumin (OVA)-specific antibody (Ab) responses following mucosal immunization. Mice given nasal OVA plus an adenovirus expressing Flt3 ligand (Ad-FL) showed early expansion of CCR5+/CCR6+/CD11b+/CD11c+ DCs in nasopharyngeal-associated lymphoid tissue (NALT) and cervical lymph nodes (CLNs). Subsequently, this DC subset became resident in submandibular glands (SMGs) and nasal passages (NPs) in response to high levels of CCR-ligands produced in these tissues. CD11b+/CD11c+ DCs were markedly decreased in both CCR5{-}/{-} and CCR6{-}/{-} mice. Chimera mice reconstituted with bone marrow cells from CD11c-diphtheria toxin receptor (CD11c-DTR) and CCR5{-}/{-} or CD11c-DTR and CCR6{-}/{-} mice given nasal OVA plus Ad-FL had elevated plasma IgG, but reduced IgA as well as low anti-OVA secretory IgA (SIgA )Ab responses in saliva and nasal washes. These results suggest that CCR5+CCR6+ DCs play an important role in the induction of Ag-specific SIgA Ab responses.
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