BioAcyl Corp
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Vaughn, A. R., Davis, M. J., Sivamani, R. K., & others. (2018). A Concise Review of the Conflicting Roles of Dopamine-1 versus Dopamine-2 Receptors in Wound Healing. Molecules, 23(1). Added by: Dr. Enrique Feoli (04/03/2022, 14:06) Last edited by: Dr. Enrique Feoli (04/03/2022, 14:18) |
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| Resource type: Journal Article Published DOI: 10.3390/molecules23010050 BibTeX citation key: Vaughn2018 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Trace Amines Creators: Davis, others, Sivamani, Vaughn Collection: Molecules |
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| Abstract |
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Catecholamines play an important regulatory role in cutaneous wound healing. The exact role of dopamine in human epidermis has yet to be fully elucidated. Current published evidence describes its differential effects on two separate families of G protein coupled receptors: D1-like and D2-like dopamine receptors. Dopamine may enhance angiogenesis and wound healing through its action on dopamine D1 receptors, while impairing wound healing when activating D2 receptors. This review summarizes the evidence for the role of dopamine in wound healing and describes potential mechanisms behind its action on D1 versus D2-like receptors in the skin.
Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
| Notes |
D1 and D2 Receptor Pathways–D1 and D2 receptors are G-protein coupled receptors that signal through different cascades. D1 receptor agonists lead to increased production of adenylyl cyclase (AC) via a Gs pathway. Conversely, agonism of D2 receptors stimulates Gi proteins leading to decreased cAMP and inhibiting neuronal activity. Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |