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Meda, F., Gauron, C., Rampon, C., Teillon, J., Volovitch, M., & Vriz, S. (2015). Nerves Control Redox Levels in Mature Tissues Through Schwann Cells and Hedgehog Signaling. Antioxidants & Redox Signaling, 24(6), 299–311. Added by: Dr. Enrique Feoli (16/06/2020, 21:21) |
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| Resource type: Journal Article DOI: 10.1089/ars.2015.6380 ID no. (ISBN etc.): 1523-0864 BibTeX citation key: Meda2015 View all bibliographic details  |
Categories: Mendeley, Mendeley Subcategories: Dynamic reciprocity Creators: Gauron, Meda, Rampon, Teillon, Volovitch, Vriz Collection: Antioxidants & Redox Signaling |
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| Abstract |
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AIMS Recent advances in redox biology have emphasized the role of hydrogen peroxide (H2O2) in the modulation of signaling pathways and revealed that H2O2 plays a role in cellular remodeling in adults. Thus, an understanding of the mechanisms that control H2O2 levels in mature tissue would be of great interest. RESULTS We used a denervation strategy to demonstrate that sensory neurons are responsible for controlling H2O2 levels under normal conditions and after being lesioned. Moreover, we demonstrate that severed nerves respond to appendage amputation via the induction of Hedgehog signaling and that this signaling is responsible for H2O2 production in the wounded epidermis. Finally, we show that H2O2 and nerve growth are regulated via reciprocal action in adults. INNOVATION AND CONCLUSION These data support a new paradigm for the regulation of tissue homeostasis: H2O2 attracts nerves and nerves control H2O2 levels in a positive feedback loop. This finding suggests that the peripheral nerve redox environment could be a target for manipulating cell plasticity in adults.
Added by: Dr. Enrique Feoli |