BioAcyl Corp
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Tata, A., Chow, R. D., & Tata, P. R. (2021). Epithelial cell plasticity: Breaking boundaries and changing landscapes. EMBO reports, 22(7), e51921. Added by: Dr. Enrique Feoli (24/05/2023, 17:21) Last edited by: Dr. Enrique Feoli (25/05/2023, 19:13) |
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| Resource type: Journal Article DOI: https://doi.org/10.15252/embr.202051921 BibTeX citation key: Tata2021 View all bibliographic details  |
Categories: BioAcyl Corp Subcategories: Cell plasticity Creators: Chow, Tata, Tata Collection: EMBO reports |
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| Abstract |
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Abstract Epithelial tissues respond to a wide variety of environmental and genotoxic stresses. As an adaptive mechanism, cells can deviate from their natural paths to acquire new identities, both within and across lineages. Under extreme conditions, epithelial tissues can utilize “shape-shifting” mechanisms whereby they alter their form and function at a tissue-wide scale. Mounting evidence suggests that in order to acquire these alternate tissue identities, cells follow a core set of “tissue logic” principles based on developmental paradigms. Here, we review the terminology and the concepts that have been put forward to describe cell plasticity. We also provide insights into various cell intrinsic and extrinsic factors, including genetic mutations, inflammation, microbiota, and therapeutic agents that contribute to cell plasticity. Additionally, we discuss recent studies that have sought to decode the “syntax” of plasticity—i.e., the cellular and molecular principles through which cells acquire new identities in both homeostatic and malignant epithelial tissues—and how these processes can be manipulated for developing novel cancer therapeutics.
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| Notes |
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(A) During development and homeostasis, self‐renewing stem cells divide and generate progenitors, which are destined to form mature differentiated cells. (B) Mature cells may dedifferentiate and give rise to stem cells following injury or cell ablation. (C) Tissue injury may induce mature differentiated cells to change their cell fate, either directly or indirectly through reversion to a progenitor cell in a process called transdifferentiation. (D) In response to injury, a reserve stem cell population can be activated and contribute to generation of active stem cells, which in turn generate committed progenitors and mature differentiated cells. (E) In transdetermination, a self‐renewing progenitor cell transforms into another type of progenitor cell. (F) In response to acute injury, mature differentiated cells undergo activation of auto degradative responses and re‐enter the cell cycle to become proliferative in a process called paligenosis. Dashed lines indicate lineage reversion. Added by: Dr. Enrique Feoli Last edited by: Dr. Enrique Feoli |
